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PROTON TRANSPORT GROUP |
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Members |
CURRENT MEMBERS LISTED
Dr. Yu-Ling Ma BSc, PhD
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I graduated in biology from Peking University. My interest in using modern scientific
methods to study Chinese herbal medicine led me to a research position in the
China Academy of Chinese Medical Sciences to investigate
the cardioprotective effects of herbal extracts using in vivo ischemia and in vitro cellular electrophysiology
experimental models. Then in the early 1990’s, I had the opportunity to work as
a visiting scholar in the Department of Pharmacology, UMDS at St. Thomas’
Hospital, London, where, under the supervision of Professor Alison Gurney, I
used patch clamp techniques to study the effects of drugs on the electrophysiological
properties of cardiac myocytes. At
the end of this research, which was supported by an ORS award and a K. C. Wong
Scholarship, I was awarded a PhD degree by the University of London in
1995. I was then offered a
Research Fellow position in UMDS to work on a pharmaceutical project to study
the antidotal effect of alpha-1-acid glycoprotein on antidepressant induced sodium
channel blockade. This project was led by the late Professor John Henry, and
soon after the start of the project, I followed Professor Henry to the
St.Mary’s campus of Imperial College London to continue the research project. Apart from
working in the field of cardiac cellular electrophysiology, I have also worked
in the field of neuron electrophysiology to study the effect of
phytocannabinoids on cerebellum brain slices, using single and multi-cellular
electrophysiology techniques. Afterwards,
I took up my current research position in Professor Vaughan-Jones’ laboratory. Selected Publications: Yu-ling Ma, Samantha E. Weston, Ben J. Whalley and
Gary J. Stephens (2008). The phytocannabinoid Δ9-tetrahydrocannabivarin
modulates inhibitory neurotransmission in the Cerebellum British J Pharmacology: 154, 216-225 Jon .A. Farrimond, Yu-ling Ma, S Nasuto, Gary J.
Stephens, Ben J. Whalley (2007). NoLITiV: an implementation of nonlinear
methods of signal processing: application to pharmacological data. BPS Winter
Meeting, Brighton, Winter 2007; Proceedings of
the British Pharmacological Society at http://www.pa2online.org/ Yu-ling Ma, Ben J.
Whalley, Gary J. Stephens (2006). The
phytocannabinoid Δ9-tetrahydrocannabivarin odulates synaptic
transmission at central inhibitory synapses. Proceedings of the British
Pharmacological Society at http://www.pA2online.org/abstracts/Vol4Issue2abst088P.pdf. Yu-ling Ma, Susan Bates & Alison Gurney (2006).
The effects of paeonol on the electrophysiological properties of cardiac
ventricular myocytes. European Journal
of Pharmacology. 545:87-92 Yu-ling Ma, Nicholas S Peters & John A Henry (2006).
α1
-Acid glycoprotein reverses cocaine-induced sodium channel blockade in
cardiac myocytes. Toxicology 220, p46-50 Yu-ling Ma & John A Henry (2001) The
antidotal effect of alpha-1-acid glycoprotein on amitriptyline toxicity in
cardiac myocytes. Toxicology Vol. 169, p.133-144 Oleg
Tolmachov, Yu-Ling Ma, Michael Themis, Pravina Patel, Hilmar Spohr, Yvonne
Kienast1, Charles Coutelle1, Nicholas S Peters (2006).
Connexin43 Transduction of Skeletal Myoblasts Improves Their Electrical
Coupling with Cardiac Myocytes. BMC
Cardiovascular Disorders.
6:25 (http://www.biomedcentral.com/1471-2261/6/25)
Ma, Y., Tolmachov, O., Themis, M., Hilmar,
S., Kienast, Y., Coutelle C., Peters N (2004). Field Action Potential
Activation and Propagation in Cocultured Cardiac Myocytes and Cx43 Transduced
Skeletal Myoblasts in a Multi-Electrode Array. Heart Vol 90:
Supplement II A37 Ma, Y., Tolmachov, O., Themis, M., Hilmar,
S., Kienast, Y., Coutelle C., Peters N (2003). Functional coupling of Cx43
transduced skeletal myoblasts with cardiac myocytes in coculture. Circulation
Vol 108 (17): 1392 Ma YL; Tolmachov O; Themis M; Poznansky M; Coutelle C; Peters NS.
( 2002). Enhanced gap-junctional coupling in connexin43 transduced skeletal
myoblasts. Circulation 106:
281 Ma, Y., Tolmachov, O., Themis, M., Poznansky,
M., Coutelle C., Peters N (2002). Intercellular communication in connexin 43 transduced skeletal
myocytes. European Heart Journal, August/September 2002 (Supplement),
Vol. 23, P. 42. Yu-ling Ma & John A Henry (1998) Administration of alpha-1-acid glycoprotein and
reduction of amitriptyline toxicity. J. Accident & Emergency Medicine
15(6): 412P Yu-ling Ma
& A M Gurney (1995) The effect of paeonol on the action potential and
ionic currents of guinea-pig ventricular myocytes. British J. Pharmacology. 116(Proceedings Suppl): 453P Ma Yu-ling, Li Lian-da at al.
(1986) Effect of quinidine and Paeonia suffruticosa on action potential of
cultured myocardial cells. Chinese J.
Integrated Traditional and Western Medicine. 6:5 p.292-294 Ma Sheng-xing, Chen Ke-ji, Ma Yu-ling (1986) Effects of alkaloids of Corydalis yanhusuo on ECG of rabbits and observation on time and dose effect relationship. Chinese J. Integrated Traditional and Western Medicine. 6:12 p.743-746 |