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PROTON TRANSPORT GROUP |
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Research |
RESEARCH INTERESTS
Regulation of Intracellular pH in heart
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The ion transporters involved Our laboratory was the first to identify functionally three of the principal transporters involved in pHi regulation, the Cl-HCO3- exchanger (Anion Exchanger, AE), the Na-HCO3 cotransporter (NBC) and a Cl-OH exchanger (CHE). All except CHE have now been cloned although the precise NBC and AE isoforms that contribute functionally to pHi control in the heart have yet to be determined. The basic kinetic characteristics of the four principal transporters, NHE, AE, NBC & CHE have been mapped out, particularly their dependence on intracellular and extracellular pH levels. When inserted into a computational model these pH dependencies accurately predict the time course of response of whole cell pHi to acute intracellular or extracellular acid/base loads. |
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To read more about our research please click on the titles below: |
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The ion transporters involved |