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PROTON TRANSPORT GROUP |
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Principal Investigators |
Research |
Wellcome Trust Heart Physiome Project
RESEARCH INTERESTS
Regulation of Intracellular pH in heart
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Importance of pHi Intracellular pH (pHi) is a major modulator of cardiac function. Its value is normally kept within strict limits (7.1-7.3), although it is known to fluctuate during local changes in metabolic activity or during whole body acid-base disturbances. The pHi also declines sharply during clinical conditions such as myocardial ischaemia. Changes of pHi exert important effects on contraction and excitability. For example the acidosis during ischaemia is one of the main causes of acute contractile depression and triggered arrhythmia. We are investigating how intracellular pH is regulated and how its effects on cardiac function are mediated. |
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To read more about our research please click on the titles below: |
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Importance of pHi |