PROTON TRANSPORT GROUP
Intracellular pH regulation in heart

Saegusa, N, Moorhouse, E, Vaughan-Jones, RD, Spitzer, KW. (2011) Influence of pH on Ca2+ current and its control of electrical and Ca2+ signaling in ventricular myocytes . J Gen. Physiol. Oct 31;138(5):537-559.

Hulikova A, Vaughan-Jones RD, Swietach P. (2011) Dual role of CO2/HCO3(-) formula buffer in the regulation of intracellular pH of three-dimensional tumor growths. J Biol Chem. Apr 22;286(16):13815-26. Epub 2011 Feb 23.

Swietach P, Hulikova A, Vaughan-Jones RD, Harris AL. (2010) New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene Dec 16;29(50):6509-21. Epub 2010 Oct 4. Review.

Swietach P, Tiffert T, Mauritz JM, Seear R, Esposito A, Kaminski CF, Lew VL, Vaughan-Jones RD. (2010) Hydrogen ion dynamics in human red blood cells. J Physiol. Dec 15;588(Pt 24):4995-5014. Epub 2010 Oct 20.

Swietach P, Camelliti P, Hulikova A, Kohl P, Vaughan-Jones RD. (2010) Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes. Cardiovasc Res. Mar 1;85(4):729-38. Epub 2009 Oct 14.

Swietach P, Spitzer KW, Vaughan-Jones RD. (2010) Modeling calcium waves in cardiac myocytes: importance of calcium diffusion in myoplasm and sarcoplasmic reticulum. Frontiers in Bioscience Jan 1;(15) 661-680.

Swietach P, Patiar S, Supuran CT, Harris AL, Vaughan-Jones RD. (2009) The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in 3-D tumor-cell growths. J Biol Chem. Jul 24;284(30):20299-310.

Huang WC, Swietach P, Vaughan-Jones RD, Glitsch MD. (2009) Differentiation impairs low pH-induced Ca2⁺ signaling and ERK phosphorylation in granule precursor tumour cells. Cell Calcium. Apr;45(4):391-9.

Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL. (2009) Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH. J. Biol Chem. Mar 6;284(10):6126-39.

Vaughan-Jones RD, Spitzer KW, Swietach P. (2009) Intracellular pH regulation in heart. J.Mol.Cell.Cardiol. Mar;46(3):318-31 (Review)

Vaughan-Jones RD, Swietach P. (2008) Pushing and pulling the cardiac sodium/hydrogen exchanger. Circ Res. Oct 10;103(8):773-5.

Swietach P, Wigfield S, Cobden P, Supuran CT, Harris AL, and Vaughan-Jones RD. (2008) Tumor-associated carbonic anhydrase 9 spatially co-ordinates intracellular pH in three-dimensional multicellular growths J. Biol. Chem. Jul 18;283(29):20473-83.

Swietach P, Spitzer KW, Vaughan-Jones RD. (2008) Ca2⁺-mobility in the sarcoplasmic reticulum of ventricular myocytes is low. Biophys J.  Aug;95(3):1412-27.

Huang W, Swietach P, Vaughan-Jones RD, Ansorge O, Glitsch MD. (2008) Extracellular acidification elicits spatially and temporally distinct Ca2⁺ signals. Current Biology. May 20;18(10):781-5.

Swietach P, Wigfield S, Supuran CT, Harris AL, Vaughan-Jones RD. (2008) Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO₂ diffusion. BJU Int. Jun;101 Suppl 4:22-4.

Ch’en F F-T, Villafuerte FC, Swietach P, Cobden PM, Vaughan-Jones RD. (2008) S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate co-transport in the heart. British Journal of Pharmacology. Mar;153(5):972-82

Niederer SA, Swietach P, Wilson DA, Smith NP, Vaughan-Jones RD. (2008) Measuring and modeling chloride-hydroxyl exchange in the guinea-pig ventricular myocyte. Biophysical Journal. Mar 15;94(6):2385-403.

Stewart AK, Kurschat CE, Vaughan-Jones RD, Shmukler BE & Alper SL.(2007). Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain. J. Physiol. Oct 1;584(Pt 1):59-73.

Swietach P, Vaughan-Jones RD, Harris AL.(2007). Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Reviews. Jun;26(2):299-310.

Swietach P, Rossini A, Spitzer KW, Vaughan-Jones RD, (2007). H⁺ Ion Activation and Inactivation of the Ventricular Gap Junction. A Basis for Spatial Regulation of Intracellular pH. Circ Res. 100:1045-1054.

Swietach P, Spitzer KW, Vaughan-Jones RD. (2007). pH-dependence of extrinsic and intrinsic H⁺-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H+ compound. Biophys J. Jan 15;92(2):641-53.

Stewart AK, Kurschat CE, Burns D, Banger N, Vaughan-Jones RD, Alper SL.(2007). Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH. Am J Physiol Cell Physiol. Feb;292(2):C909-18.

Vaughan-Jones RD, Villafuerte FC, Swietach P, Yamamoto T, Rossini A, Spitzer KW. (2006). pH-regulated Na⁺  influx into the mammalian ventricular myocyte: the relative role of Na⁺ -H⁺ exchange and Na⁺ -HCO₃^- co-transport. Journal of Cardiovascular Electrophysiology. May;17 Suppl 1:S134-S140.

Vaughan-Jones RD, Spitzer KW, Swietach P.  (2006). Spatial aspects of intracellular pH regulation in heart muscle. Prog.Biophys.Mol.Biol. Jan-Apr;90(1-3):207-24.

Swietach P, and Vaughan-Jones R.D (2005).  Relationship between Intracellular pH and Proton Mobility in Rat and Guinea-Pig Ventricular Myocytes. The Journal of Physiology. 566(Pt 3), 793-806.

Swietach P, and Vaughan-Jones R.D (2005).  Spatial regulation of intracellular pH in the ventricular myocyte. Annals.N.Y Acad.Sci. 1047, 271-82.

Swietach P, Spitzer KW, Vaughan-Jones RD (2005). Experimental Generation and Computational Modeling of Intracellular pH Gradients in Cardiac Myocytes. Biophysical Journal. 88(4), 3018-3037.

Yamamoto T, Swietach P,  Rossini A,  Loh SH, Vaughan-Jones RD, and Spitzer K.W. (2005). Functional Diversity of Electrogenic Na⁺-HCO₃^-
Co-transport in Ventricular Myocytes from Rat, Rabbit and Guinea Pig. J. Physiol.  562.2, 455-475.

Stewart AK, Kerr N, Chernova MN,  Alper SL, and Vaughan-Jones RD (2004).  Acute pH-dependent regulation of AE2-mediated anion exchange involves discrete local surfaces of the N-terminal cytoplasmic domain.  Journal of Biological Chemistry.  279, 52664-52676.

Swietach P, and Vaughan-Jones RD (2004).  Novel Method for Measuring Junctional Proton Permeation in Isolated Ventricular Myocyte Cell Pairs.  American Journal of Physiology. 287: H2352-H2363.

Zaniboni M, Rossini A, Swietach P, Banger N, Spitzer KW, and Vaughan-Jones RD. (2003).  Proton Permeation Through the Myocardial Gap Junction. Circulation Research. 93, 726-735.

F-T Ch'en F, Dilworth E, Swietach P, Goddard SR, and Vaughan-Jones R.D (2003).  Temperature dependence of Na⁺-H⁺ exchange, Na⁺-HCO₃^- co-transport, intracellular buffering and intracellular pH in guinea pig ventricular myocytes. J. Physiol. 552, 715-726.

Zaniboni M, Swietach P, Rossini A, Yamamoto T, Spitzer KW, Vaughan-Jones RD. (2003).  Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit and guinea pig. American Journal of Physiology. 285(3), H1236-46.

Swietach P, Zaniboni M, Stewart AK, Rossini A, Spitzer KW, Vaughan-Jones RD. (2003). Modelling Intracellular H⁺ ion diffusion.   Prog.Biophys.Mol.Biol. 83(2), 69-100.

Spitzer KW, Vaughan-Jones RD. (2003).  Regulation of Intracellular pH in mammalian cells. In: The Sodium-Hydrogen Exchange: From Molecule To Its Role In Disease.  Edited by Karmazyn. M, Avkiran. M, and Fliegel.L. Kluwer Academic Publishers, Chapter 1. ISBN:1-4020-7474-3.

Vaughan-Jones RD and Spitzer KW (2002).   Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte. Biochemistry and Cell Biology. 80(5), 579-596.

Vaughan-Jones RD, Peercy BE, Keener JP, and Spitzer KW (2002).  Intrinsic H⁺ ion mobility in the mammalian ventricular myocyte. J.Physiol. 541.1,  139-158.

Spitzer KW , Skolnick RL,  Peercy BE,  Keener JP, and Vaughan-Jones RD. (2002).  Facilitation of intracellular H ⁺ ion mobility by CO₂/HCO₃^- in rabbit ventricular myocytes is regulated by carbonic anhydrase J.Physiol. 541.1, 159-167.

Virkki LV, Wilson DA, Vaughan-Jones RD, and Boron WF. (2002).  Functional characterization of human NBC4 as an electrogenic Na/HCO₃^- cotransporter (NBCe2).   Am. J.Physiol Cell Physiol 282,  C1278-C1289.

Loh SH, Tsai CS, Lin CI, Jin JS, Vaughan-Jones RD. (2001).  Effect of S20787, a novel Cl^--HCO₃^- exhange inhbitor,on intracellular pH regulation in guinea pig ventricular myocytes. J.Biomed.Sci. 8(5), 395-405.

Balnave CD, and Vaughan-Jones, RD.  (2000). Effect of intracellular pH on spontaneous Ca²⁺ spark frequency in rat ventricular myocytes.  J.Physiol. 528, 25-37.

Dasso LLT, Buckler KJ, and Vaughan-Jones RD. (2000).  Interactions between hypoxic and hypercapnic stimuli on calcium signalling in carotid body type-1 cells.  Am.J.Physiol (Lung Cell Mol Physiol). 279, 36-42.

Tsai K-L, Vaughan-Jones RD, and Buckler KJ. (2000).  A dual-acid influx transport system in the carotid body type I cell.Adv.Exp.Med.Biol. 475, 723-32.

Spitzer KW, Ershler PR, Skolnick RL and Vaughan-Jones RD. (2000).  Generation of intracellular pH gradients in single cardiac myocytes with a microperfusion system. Am.J.Physiol., 278, H1371-82.

Sun B, Vaughan-Jones RD and J-I Kambayashi. (1999).  Two distinct HCO₃^--dependent H⁺ efflux pathways in human vascular endothelial cells.  Am. J.Physiol. 277, H28-32.

Leem CH, Lagadic-Gossmann D and Vaughan-Jones RD. (1999).  Characterization of intracellular pH-regulation in the guinea-pig ventricular myoctye. J.Physiol., 517.1,159-80.

Stewart AK, Boyd CAR and Vaughan-Jones RD. (1999).  A novel role for carbonic anhydrase: cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes. J.Physiol. 516.1, 209-17.

Buckler KJ and Vaughan-Jones RD. (1998).  Effects of mitochondrial uncouplers on intracellular calcium,pH and membrane potential in rat carotid body type-I cells. J.Physiol. 513.3, 819-33.

Leem CH and Vaughan-Jones RD. (1998).  Sarcolemmal mechanisms for pH_i recovery from alkalosis in the guinea pig ventricular myocyte. J.Physiol. 509.2, 487-96.

Leem CH and Vaughan-Jones RD. (1998).   Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte.  J.Physiol.  509.2, 471-85.

Ch’en FF-T, Vaughan-Jones RD, Clarke K and Noble D. (1998).  Modelling myocardial ischaemia and reperfusion. Prog.Biophys.Mol.Biol.69, 515-38.

Temple CS,  Stewart AK, Meredith D,  Lister NA,  Morgan KM, Collier ID, Vaughan-Jones RD,  Boyd CAR,  Bailey PD and Bronk JR  (1998).  Peptide mimics as substrates for the intestinal peptide transporter. J.Biol.Chem. 273, 20-2.