PROTON  TRANSPORT  GROUP
Intracellular pH regulation in heart

Group Leader Prof. Richard Vaughan-Jones

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CURRENT MEMBERS LISTED

Philip Cobden BHF  Research Assistant

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University Laboratory of Physiology Parks Road, Oxford, OX1 3PT. (+44)- 1865-272500 (Switchboard) (+44)- 1865-272469 (Fax) .

I completed my MSc in Neuroscience from the University of Oxford in 2003, and started in the Proton Transport group, as the Laboratory Manager/ Research Assistant in April 2005.
I am responsible for general laboratory management consisting of five laboratories, including the confocal microscopy imaging suite,Oxford Cardiac Research Group molecular biology facility and laboratories concerned with research in single cell photometry, patch clamp and voltage clamp. I am the buyer for the group, and I am responsible for administering all laboratory funds.

Recent publications:

Swietach P, Wigfield S, Cobden P, Supuran CT, Harris AL, and Vaughan-Jones RD. (2008) Tumor-associated carbonic anhydrase 9 spatially co-ordinates intracellular pH in three-dimensional multicellular growths J. Biol. Chem. Jul 18;283(29):20473-83.

Ch’en F F-T, Villafuerte FC, Swietach P, Cobden PM, Vaughan-Jones RD. (2008) S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate co-transport in the heart. British Journal of Pharmacology. Mar;153(5):972-82

Ferraguti F, Klausberger T, Cobden P, Baude A, Roberts JD, Szucs P, Kinoshita A, Shigemoto R, Somogyi P, Dalezios Y.(2005) Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus.
J Neurosci. Nov 9;25(45):10520-36.

Ferraguti F, Cobden P, Pollard M, Cope D, Shigemoto R, Watanabe M, Somogyi P.(2004) Immunolocalization of metabotropic glutamate receptor 1alpha (mGluR1alpha) in distinct classes of interneuron in the CA1 region of the rat hippocampus. Hippocampus.14(2),193-215.

Klausberger T, Magill PJ, Marton LF, Roberts JD, Cobden PM, Buzsaki G, Somogyi P.(2003) Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo. Nature. Feb 20; 421(6925), 844-8.

Cope DW, Maccaferri G, Marton LF, Roberts JD, Cobden PM, Somogyi P.(2002) Cholecystokinin-immunopositive basket and Schaffer collateral-associated interneurones target different domains of pyramidal cells in the CA1 area of the rat hippocampus. Neuroscience. 109(1), 63-80.

Dr. Pawel Swietach BA, DPhil

Mr Francisco C. Villafuerte BSc