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PROTON TRANSPORT GROUP |
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Research |
RESEARCH INTERESTS
Regulation of Intracellular pH in heart
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Molecular basis of pH sensing by acid/base transporters Sarcolemmal transporters involved in pHi regulation are kinetically governed by pH on either side of the membrane. There are extracellular and intracellular sites on the transport molecule that sense the local pH, and then allosterically increase acid or base transport out of the cell. We are currently using site directed mutagenesis to explore the molecular basis of this pH regulation of ion transport, using gene products of the AE family of Cl-HCO3- transporters, notably AE-2 and AE-3, both of which, when expressed in Xenopus oocytes, show a steep dependence of activity on pHi and pHo. |
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To read more about our research please click on the titles below: |
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Molecular basis of pH sensing by acid/base transporters |