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PROTON TRANSPORT GROUP |
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Members |
CURRENT MEMBERS LISTED
Dr Jae Boum Youm BHF Research Scientist
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My career has been dedicated to understanding the role of ion channels in cardiac cellular physiology, and to developing an integrated mathematical model of the atrial myocytes and interstitial cells of Cajal (ICC). I grew up in Seoul, Korea and graduated from Seoul National University College of Medicine in 1993 to be a medical doctor. After 3 years of clinical practice in Yeonchon Medical Center, I began and completed my Ph.D. in Seoul National University College of Medicine under the supervision of Professor Earm Yung E to investigate the role of ion channels in the mediation of ANP release (1996-2001). I became a lecturer (2000) and an assistant professor (2002) of Department of Physiology, Cheju National University, Jeju, where I gave a lecture on medical physiology and investigated the pacemaker mechanism of ICC. Then I moved to Inje University College of Medicine, Busan, where I joined a laboratory of Mitochondrial Research Group to investigate the role of mitochondria in the ischaemia-reperfusion injury in 2004. Three years later, I became an associate professor of Department of Physiology. Since 2009, I have been a Visiting Research Scientist in Professor Vaughan-Jones’ laboratory in Oxford, studying the mechanism of pHi regulation in cardiac myocytes. SELECTED
PUBLICATIONS
1.
Park
SJ, Choi KS, Shin DH, Kim JS, Jang DS, Youm JB, Choe H, Earm YE, Kim
SJ. Effects of Mixed Herbal Extracts from Parched Puerariae Radix, Gingered
Magnoliae Cortex, Glycyrrhizae Radix and Euphorbiae Radix (KIOM-79) on
Cardiac Ion Channels and Action Potentials. J Korean Med Sci. 24:
403-412. (2009) 2.
Youm
JB, Leem CH,
Zhang YH, Kim N, Han J, Earm YE. Modeling of Arrhythmogenic Automaticity
Induced by Stretch in Rat Atrial Myocytes. Korean J Physiol Pharmacol.
12: 267-274. (2008) 3.
Zhang
YH, Youm JB, Earm YE. Stretch-activated non-selective cation channel:
A causal link between mechanical stretch and atrial natriuretic peptide
secretion. Prog Biophys Mol Biol 98:1-9. Review (2008) 4.
Youm
JB, Han J.
Mitochondrial Physiology, Trends in Medical Research
15(1):25-33. (2008) 5.
Cha
CY, Earm KH, Youm JB, Baek EB, Kim SJ, Earm YE. Electrophysiological
modelling of pulmonary artery smooth muscle cells in the rabbits--special
consideration to the generation of hypoxic pulmonary vasoconstriction. Prog
Biophys Mol Biol 96(1-3):399-420. (2008) 6.
Seol
CA, Kim WT, Ha JM, Choe H, Jang YJ, Youm JB, Earm YE, Leem CH.
Stretch-activated currents in cardiomyocytes isolated from rabbit pulmonary veins.
Prog
Biophys Mol Biol [Epub ahead of print] (2008) 7.
Seol
CA, Kim J, Kim WT, Ha JM, Choe H, Jang YJ, Shim EB, Youm JB, Earm YE,
Leem CH. Simulation of spontaneous action potentials of cardiomyocytes in
pulmonary veins of rabbits. Prog Biophys Mol Biol 96(1-3):132-151
(2008) 8.
Youm
JB, Kim N, Han J,
Kim E, Joo H, Leem CH, Goto G, Noma A and Earm YE. A mathematical model of
pacemaker activity recorded from mouse small intestine. Philos Transact
A Math Phys Eng Sci 364:1135-1154 (2006). 9.
Leem
CH, Kim WT, Ha JM, Lee YJ, Seong HC, Choe H, Jang YJ, Youm JB and Earm
YE. Simulation of Ca2+-activated Cl- current of
cardiomyocytes in rabbit pulmonary vein: implications of subsarcolemmal Ca2+
dynamics. Philos Transact A Math Phys Eng Sci 364:1223-1243
(2006). 10.
Youm
JB, Han J, Kim N,
Zhang YH, Kim E, Joo H, Hun Leem C, Joon Kim S, Cha KA and Earm YE. Role of
stretch-activated channels on the stretch-induced changes of rat atrial myocytes.
Prog Biophys Mol Biol 90:186-206 (2006). 11.
Youm
JB, Han J,
Kim Nari, Kim E, Leem CH, Kim SJ, Earm YE. Role of stretch-activated channels
in the heart: action potential and Ca2+ transients. “Mechanosensitivity
in Cells and Tissues” in Academia 103-125 (2005). 12. Youm JB, Earm YE and Ho WK. Modulation of HERG channel inactivation by external cations. Eur Biophys J 33:360-369 (2004). 13. Youm JB, Jo SH, Leem CH, Ho WK and Earm YE. Role of stretch-activated channels in stretch-induced changes of electrical activity in rat atrial myocytes. Kor J Physiol 8:33-41 (2004). 14. Youm JB. Stretch-activated K+
channels in rat atrial myocytes. Kor J Physiol 7: 341-348 (2003). |