Book Chapters

Physiology of the Intervertebral disc. Jing Yu, Thijs Grunhagen, Conny Neidlinger-Wilke, Sally Roberts, Jill Urban. In, Non-fusion treatments for Disc Degeneration. Edited by M Spalzki and R Gunzburg (In press).

The intervertebral disc - normal, ageing and pathological. Urban J, Roberts S. In: Rothman-Simeone - The Spine (editor S Garfin) (In press)

Why do intervertebral discs degenerate? - Presentation of the European research project EURODISC by Cornelia Neidlinger-Wilke, Jill Urban, Sally Roberts, Alice Maroudas, Sarit Sivan, Dimitris Kletsas, Tapio Videman, Michele Battie, Jacques Huyghe In: Ergomechanics II, Editor: H-J. Wilke, Shaker-Verlag, Germany, (2006)

Refereed Papers and Reviews

Diurnal fluid expression and the activity of intervertebral disc cells. S.Sivan, K Wurtz, C Niedlinger-Wilke, A Maroudas, JPG Urban. Biorheology, (in press)

Nutrient supply and intervertebral disc metabolism. Thijs Grunhagen, Geoff Wilde, Dahbia Mouhkbi -Soukane, Saeed A Shirazi-Adl, JPG Urban. Journal of Bone and Joint Surgery A (In press)

Metabolism of the Intervertebral Disc: Effects of Low Levels of Oxygen, Glucose, and pH on Rates of Energy Metabolism of Bovine Nucleus Pulposus Cells. Bibby SR, Jones DA, Ripley RM, and Urban JPG. Spine 2005;30:487-96.

Physiology of the Normal and Pathological Disc; Can it give clues for diagnostic imaging. JPG Urban and CP Winlove. Journal of Medical Resonance Imaging (In press).

Diffusivities of solutes in the intervertebral disc; their relevance in regard to solute transport. Olga Boubriak and Jill Urban (submitted to Spine)

Human intervertebral disc aggrecan inhibits endothelial cell adhesion and migration in vitro. WEB Johnson, B Caterson, SM Eisenstein and S Roberts (2005) Spine 30: 1139-1147.

Inflammatory Mediators as Potential Therapeutic Targets in the Spine. S Roberts and RC Butler. Current Drug Targets – Inflammation & Allergy 2005 4 89-98

Human intervertebral disc cells promote nerve growth over substrata of human intervertebral disc aggrecan. WEB Johnson, S Sivan, KT Wright, SM Eisenstein, A Maroudas and S Roberts Spine. (In Press)

Topographical guidance of intervertebral disc cell growth in vitro: towards the development of tissue repair strategies for the anulus fibrosus. WEB Johnson, A Wootton, A El Haj, SM Eisenstein, A Curtis and S Roberts Eur. Spine J (In Press)

Senescence in Human Intervertebral Discs. S Roberts, EH Evans, D Kletsas, DC Jaffray and SM Eisenstein Eur. Spine J (In Press)

Histology and Pathology of the Human Intervertebral Disc. S Roberts, EH Evans, J Trevedi and J Menage. Journal of Bone and Joint Surgery (In Press).

Human intervertebral disc cell morphology and cytoskeletal composition: a preliminary study of regional variations in health and disease. WEB Johnson and S Roberts (2003) J Anat 203:605-612

Nutrition of the intervertebral disc. Urban JPG, Smith SR, Fairbank JCT. (2004) Spine 29 (23): 2700-2709.

Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose and pH on rates of energy metabolism of bovine nucleus pulposus cells. SRS Bibby, DA Jones, RM Ripley, JPG Urban, Spine 2004 (in press).

Human Intervertebral Disc Cells Promote Nerve Growth Over Substrata of Human Intervertebral Disc Aggrecan. Johnson, WEB., Sivan, S., Wright, KT., Eisenstein, S.M., Maroudas, A., and Roberts, S. (Invited paper). Spine, 2005. ( In Press).

Correlation of Swelling Pressure and Intra-Fibrillar Water in Young and Aged Annuli of Human Intervertebral Discs. Sivan, S., Wachtel, E., Merkher, Y., Maroudas, A. (In Press).

Racemization of Aspartic Acid as a Measure of Turnover Rate in Normal and Degenerate Human Intervertebral Discs. Sivan, S., Tsitron, E., Roughley, P., Sakkee, AN., van-der Ham, F., DeGroot, J., and Maroudas, A. (Submitted).

Non-Enzymatic Glycation of Human Intervertebral Disc Constituents as Measure of Turnover. Sivan, S., Tsitron, E., Roughley, P., DeGroot, J., Verzijl, N., Bank, R.A., Merkher, Y., Maroudas. (Submitted).

The Effect of Polyanion Concentrations on the Ionic Composition of the Intervertebral Disc. Sivan, S., Bibby, SRS., Urban, MR., Urban JPG., Merkher, Y., Lulu, A., Maroudas, A. (Submitted)

Human intervertebral disc aggrecan inhibits endothelial cell adhesion and cell migration in vitro. Johnson WEB, Caterson B, Eisenstein SM, Roberts S. (2004) Spine (In press)

A three-dimensional collagen matrix as a suitable culture system for the comparison of cyclic strain and hydrostatic pressure effects on intervertebral disc cells. C. Neidlinger-Wilke , K. Würtz , A. Liedert , C. Schmidt, W. Börm, A. Ignatius, HJ. Wilke, L. Claes: J Neurosurg. 2: 457-465, 2005)

Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure. C. Neidlinger-Wilke, K. Würtz, J. PG. Urban, W. Börm, A. Ignatius, H.-J. Wilke, L. Claes. (under review for a special supplement of the European Spine Journal)

Cells from the distinct regions of the intervertebral disc differ in terms of their mechano-sensitivity. K. Würtz; J. Urban; A. Ignatius; H.-J. Wilke; L. Claes; C. Neidlinger-Wilke. (under review by the European Spine Journal)

The occurrence of anular tears and their relation to lifetime back pain history: a cadaveric study using barium sulfate discography. Videman T, Nurminen M. (2004) Spine 29 (23): 2668-2676.

Focus paper: Lumbar disc degeneration: epidemiology and genetic influences. Battié MC, Videman T, Parent É. (2004) Spine 29 (23): 2679-2690

The Role of Genetics and Environment in Lifting Force and Isometric Trunk Extensor Endurance. Ropponen A, Levalähti E, Videman T, Kaprio J, Battié MC. Physical Therapy. 2004;84:608-621

Multivariate genetic analysis of lifetime exercise and environmental factors. Simonen R, Levälahti E, Kaprio J, Videman T, Battié MC. Med Sci Sports Exerc 36(9):1559-1566, 2004.

Isometric back extension endurance testing: reasons for test termination. Ropponen A, Gibbons LE, Videman T, Battié MC. J Orthop & Sports Phys Ther 35(7):437-442; 2005

Low Back Pain among Nurses A follow-up beginning at entry to the nursing school. Videman T, Riihimäki H, Troup JDG. Spine 30(20):2334-41; 2005

Anthropometrics and Biochemical Markers in Men. Donescu OS,. Battié MC, Videman T, Risteli J, Eyre D. J Clin Densitometry 8(2):222- 227, Jul 2005

Determinants of the Progression in Lumbar Degeneration: A 5-year Follow-up Study of Adult Male Monozygotic Twins. Videman T, Battié MC, Ripatti S, Gill K, Manninen H, Kaprio J Spine 30. In press.

Prevalence and characteristics of upper or mid-back pain in Finnish men. Niemeläinen R, Videman T, Battié MC. Spine. In press.

The Predictive Role of Bone Turnover Markers for BMD in Men. Donescu OS,. Battié MC, Videman T, Risteli J, Eyre D. J Clin Densitometry. Submitted.

Differential proliferative response of fetal and adult human skin fibroblasts to TGF-ß. Pratsinis H, Giannouli CC, Zervolea I, Psarras S, Stathakos D, Kletsas D. (2004) Wound Repair and Regeneration 12: 374-383.

The pro-inflammatory phenotype of senescent cells: the p53-mediated ICAM-1 expression. Kletsas D, Pratsinis H, Mariatos G, Zacharatos P, Gorgoulis VG. (2004) Annals of the New York Academy of Sciences 1019: 330-332.

The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndrome. Zervolea I, Pratsinis H, Tsagarakis S, Karavitaki N, Stathakos D, Thalassinos N, Kletsas D. (2005) Eur. J. Endocrinol. 152:895-902.

p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions. Gorgoulis VG, Pratsinis H, Zacharatos P, Demoliou C, Sigala F, Asimacopoulos PJ, Papavassiliou AG, Kletsas D. (2005) Lab. Invest. 85:502-511.

Uniaxial tensile testing of canine annulus fibrosus tissue under changing salt concentrations. Huyghe JM, Drost MR. (2004) Biorheology 41: 255-261.

Bioengineering: the future of poromechanics? Huyghe JM, Schroeder Y, Baaijens FPT. Proceedings of the 17th ASCE Engineering Mechanics Conference. 13-16 June 2004.

Influence of osmotic pressure changes on the opening of existing cracks in two intervertebral disc models. S. Wognum, J.M. Huyghe, F.P.T. Baaijens; accepted at Spine, 2005

Osmoviscoelastic finite element model of the intervertebral disc. Y. Schroeder, W. Wilson, J.M. Huyghe, F.P.T. Baaijens; submitted to European Spine Journal, 2005